HIPK3

Across TCGA patient cohorts, HIPK3 mutation is significantly associated with the RNA expression of many other genes, with 4,536 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIPK3-associated genes across cancer lineages are CDK1, ZWINT, and RBM17. Each is linked with HIPK3 in more than 4 cancer types. Because this analysis shows association rather than direction, both HIPK3-to-partner and partner-to-HIPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK1 grouped by HIPK3-low versus HIPK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIPK3→partner) and Y-score (partner→HIPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDK1 →	+0.525	+1.747	.003	.003	3	5
UCEC	ZWINT →	+0.709	+2.020	<.001	<.001	3	4
UCEC	RBM17 →	+0.258	+1.221	.005	.009	3	4
UCEC	CDC6 →	+0.879	+1.699	<.001	<.001	3	4
UCEC	OXSM →	+0.235	+1.411	.004	.008	3	3
UCEC	SKA1 →	+0.767	+4.413	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,536 associations by consensus.

CDK1 by HIPK3 expression — UCEC

Explore this box plot interactively →