HIPK3

Across TCGA patient cohorts, HIPK3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIPK3-associated genes across cancer lineages are ASNS, ATM, and TFRC. Each is linked with HIPK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HIPK3-to-partner and partner-to-HIPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by HIPK3-low versus HIPK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIPK3→partner) and Y-score (partner→HIPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.319	+1.584	.003	.017	3	3
UCEC	ATM →	-0.545	-3.074	<.001	<.001	3	3
UCEC	TFRC →	+0.568	+2.999	<.001	<.001	3	2
UCEC	eEF2 →	+0.226	+1.064	.039	.048	3	2
UCEC	FOXO3a_pS318_S321 →	-0.090	-1.504	.018	.014	3	2
UCEC	GAPDH →	+0.328	+1.584	.046	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

ASNS by HIPK3 expression — UCEC

Explore this box plot interactively →