HIPK3

Across TCGA cell cohorts, HIPK3 mutation is significantly associated with the RNA expression of many other genes, with 194 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HIPK3-associated genes across cancer lineages are TTPA, SLC38A8, and SLC6A18. Each is linked with HIPK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HIPK3-to-partner and partner-to-HIPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTPA grouped by HIPK3-low versus HIPK3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIPK3→partner) and Y-score (partner→HIPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TTPA →	+0.148	+3.579	<.001	.007	3	2
BLOOD_Lymphoma	SLC38A8 →	+0.079	+4.928	<.001	<.001	3	2
LARGE_INTESTINE	SLC6A18 →	+0.164	+3.363	<.001	.004	3	2
SOFT_TISSUE	C20orf85 →	+0.115	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR1L4 →	+0.072	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR4D6 →	+0.046	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 194 associations by consensus.

TTPA by HIPK3 expression — BLOOD_Lymphoma

Explore this box plot interactively →