HIPK1

Across TCGA patient cohorts, HIPK1 mutation is significantly associated with the RNA expression of many other genes, with 5,366 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIPK1-associated genes across cancer lineages are CPSF7, ZUP1, and GMEB1. Each is linked with HIPK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HIPK1-to-partner and partner-to-HIPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPSF7 grouped by HIPK1-low versus HIPK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIPK1→partner) and Y-score (partner→HIPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CPSF7 →	+0.246	+1.684	.002	.002	3	3
UCEC	ZUP1 →	+0.343	+2.180	<.001	<.001	3	3
UCEC	GMEB1 →	+0.268	+1.247	<.001	.002	3	3
UCEC	ZNF683 →	+0.669	+1.700	<.001	.001	3	3
UCEC	BNIP3 →	+0.681	+1.378	<.001	<.001	3	3
UCEC	DNAJA1 →	+0.397	+1.514	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,366 associations by consensus.

CPSF7 by HIPK1 expression — UCEC

Explore this box plot interactively →