HIPK1-AS1

Across TCGA pan-cancer cohorts, HIPK1-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HIPK1-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HIPK1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HIPK1-AS1 expression acts as an unfavorable survival marker, although some lineages such as CHOL and PAAD show a favorable association.

KIRC, CHOL, and PAAD are the cancer types where HIPK1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.420	0.623	<.001	124	view →
CHOL	DFS	Tertile	All	0.826	0.203	.001	50	view →
PAAD	OS	Median	All	0.665	0.295	<.001	38	view →
LIHC	OS	Median	All	0.705	0.851	.001	38	view →
ACC	DFS	Tertile	II,III,IV	0.422	0.771	.003	35	view →
OV	OS	Quartile	All	0.386	0.258	.004	34	view →
COAD	OS	Tertile	III,IV	0.483	0.931	.003	19	view →
LUAD	DFS	Quartile	IV	0.333	0.745	.014	18	view →
SKCM	OS	Tertile	All	0.418	0.235	.004	16	view →
READ	OS	Quartile	II,III,IV	0.693	0.260	.005	15	view →
TGCT	DFS	Median	All	0.909	0.755	.008	12	view →
UVM	DFS	Median	III,IV	0.282	0.756	.008	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HIPK1-AS1–KIRC (DFS)

Open the KIRC breakdown →