HIPK1-AS1

Across TCGA pan-cancer cohorts, HIPK1-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HIPK1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HIPK1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types HIPK1-AS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where HIPK1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HIPK1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.339	<.001	10	view →
KIRC	Male	II,III,IV	−0.162	<.001	9	view →
KICH	Male	All	−0.424	<.001	8	view →
LUSC	All	II,III,IV	−0.183	<.001	6	view →
BLCA	All	All	+0.122	.015	2	view →
BRCA	All	II,III,IV	−0.061	.027	2	view →
LUAD	All	III,IV	−0.190	.036	1	view →
KIRP	All	All	−0.124	.030	1	view →
LIHC	Male	All	+0.105	.017	1	view →
STAD	Male	IV	+0.090	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HIPK1-AS1–THCA

Open the THCA breakdown →