HIP1R

Across TCGA pan-cancer cohorts, HIP1R Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HIP1R data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher HIP1R Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HIP1R expression acts as an unfavorable survival marker, although some lineages such as STAD and SKCM show a favorable association.

BRCA, UCEC, and STAD are the cancer types where HIP1R Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	II,III,IV	0.117	0.565	.011	18	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
STAD	DFS	Median	II,III,IV	0.921	0.629	.040	2	view →
SKCM	OS	Median	All	1.000	0.777	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HIP1R–BRCA (OS)

Open the BRCA breakdown →