HIP1R

Across TCGA pan-cancer cohorts, HIP1R mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HIP1R data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HIP1R mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HIP1R expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and UCEC are the cancer types where HIP1R mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	1.000	0.548	<.001	45	view →
PDAC	DFS	Quartile	II,III,IV	0.523	0.166	.011	26	view →
UCEC	OS	Median	All	0.981	0.852	.010	18	view →
CCRCC	DFS	Median	All	0.924	0.524	.008	15	view →
LUAD	OS	Median	III,IV	0.808	0.410	.025	8	view →
HNSC	DFS	Median	All	0.863	0.700	.012	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HIP1R–LSCC (DFS)

Open the LSCC breakdown →