HINT2P1

Across TCGA pan-cancer cohorts, HINT2P1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated HINT2P1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HINT2P1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HINT2P1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and PAAD show a favorable association.

COAD, LUSC, and SKCM are the cancer types where HINT2P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	All	0.540	0.880	<.001	54	view →
LUSC	DFS	Tertile	All	0.870	0.628	.013	45	view →
SKCM	DFS	Tertile	All	0.064	0.247	<.001	39	view →
PAAD	DFS	Tertile	II,III,IV	0.803	0.259	.004	36	view →
LUAD	OS	Tertile	III,IV	0.082	0.672	<.001	36	view →
DLBC	DFS	Tertile	IV	0.120	0.683	.001	36	view →
ESCA	DFS	Tertile	III,IV	0.570	0.260	.013	30	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	18	view →
STAD	OS	Tertile	IV	0.052	0.541	.003	18	view →
BRCA	DFS	Tertile	II,III,IV	0.810	0.895	.032	12	view →
MESO	DFS	Tertile	IV	0.132	0.405	.041	9	view →
LIHC	DFS	Tertile	III,IV	0.116	0.345	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

HINT2P1–COAD (OS)

Open the COAD breakdown →