HINT2

Across TCGA patient cohorts, HINT2 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,810 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HINT2-associated proteins across cancer lineages are SUPT16H, ZMYM3, and PRPF38B_S529. Each is linked with HINT2 in more than 4 cancer types. Because this analysis shows association rather than direction, both HINT2-to-partner and partner-to-HINT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HINT2 versus SUPT16H in LSCC, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HINT2→partner) and Y-score (partner→HINT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SUPT16H →	+0.388	+0.225	<.001	<.001	3	5
LSCC	ZMYM3 →	+0.310	+0.227	<.001	<.001	3	5
LSCC	PRPF38B_S529 →	+0.427	+0.239	.002	.003	3	4
HNSC	RCOR3 →	+0.514	+0.286	<.001	<.001	3	4
LSCC	RFC1 →	+0.325	+0.187	.001	.009	3	4
HNSC	RSF1 →	+0.322	+0.217	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,810 associations by consensus.

HINT2 vs SUPT16H — LSCC

Explore this scatter interactively →