HIKESHI

Across TCGA patient cohorts, HIKESHI protein abundance is significantly associated with the RNA expression of many other genes, with 4,733 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible HIKESHI-associated genes across cancer lineages are TMEM126A, USP35, and DUSP26. Each is linked with HIKESHI in more than 3 cancer types. Because this analysis shows association rather than direction, both HIKESHI-to-partner and partner-to-HIKESHI results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HIKESHI versus TMEM126A in COAD, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIKESHI→partner) and Y-score (partner→HIKESHI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TMEM126A →	+0.491	+0.257	.004	.004	3	4
HNSC	USP35 →	+0.513	+0.229	<.001	<.001	3	3
GBM	DUSP26 →	+1.433	+0.275	.001	.003	3	3
OV	GVQW3 →	+0.742	+0.519	.004	<.001	3	3
LUAD	DPP4 →	-1.276	-0.289	<.001	<.001	3	3
BRCA	ZC3H7B →	+0.550	+0.311	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,733 associations by consensus.

HIKESHI vs TMEM126A — COAD

Explore this scatter interactively →