HIKESHI

Across TCGA pan-cancer cohorts, HIKESHI RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HIKESHI’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HIKESHI RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HIKESHI is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where HIKESHI tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HIKESHI RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.588	<.001	12	view →
HNSC	All	III,IV	+0.468	<.001	10	view →
LIHC	Male	II,III,IV	+1.137	<.001	9	view →
COAD	Female	II,III,IV	+0.847	<.001	8	view →
LUAD	Male	II,III,IV	+0.616	<.001	7	view →
LUSC	All	II,III,IV	+0.576	<.001	6	view →
KIRP	All	IV	+0.925	.022	5	view →
READ	Male	All	+0.730	.004	5	view →
THCA	All	All	+0.183	.001	5	view →
KICH	All	All	−0.416	.001	4	view →
BLCA	Female	III,IV	+0.390	.030	4	view →
CHOL	All	All	+1.638	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

HIKESHI–KIRC

Open the KIRC breakdown →