HIKESHI

Across TCGA patient cohorts, HIKESHI mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIKESHI-associated genes across cancer lineages are MEK1_p_S217_S221, MSH6, and Di-Ras3. Each is linked with HIKESHI in more than 1 cancer types. Because this analysis shows association rather than direction, both HIKESHI-to-partner and partner-to-HIKESHI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1_p_S217_S221 grouped by HIKESHI-low versus HIKESHI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIKESHI→partner) and Y-score (partner→HIKESHI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1_p_S217_S221 →	+0.554	+3.169	<.001	.020	3	1
UCEC	MSH6 →	-0.633	-3.169	<.001	.020	3	1
UCEC	Di-Ras3 →	-0.167	-3.169	.040	.020	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MEK1_p_S217_S221 by HIKESHI expression — UCEC

Explore this box plot interactively →