HIKESHI

Across TCGA cell cohorts, HIKESHI RNA expression is significantly associated with the go_rna of many other GO terms, with 3,247 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible HIKESHI-associated GO terms across cancer lineages are Negative regulation of focal adhesion disassembly, Positive regulation of protein K48-linked ubiquitination, and Mitochondrial electron transport, succinate to ubiquinone. Each is linked with HIKESHI in more than 11 cancer types. Because this analysis shows association rather than direction, both HIKESHI-to-partner and partner-to-HIKESHI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of focal adhesion disassembly grouped by HIKESHI-low versus HIKESHI-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIKESHI→partner) and Y-score (partner→HIKESHI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of focal adhesion disassembly →	+0.187	+0.694	<.001	.001	3	12
STOMACH	Positive regulation of protein K48-linked ubiquitination →	+0.149	+0.877	<.001	<.001	3	12
STOMACH	Mitochondrial electron transport, succinate to ubiquinone →	+0.070	+0.712	<.001	<.001	3	12
OVARY	Mitochondrial protein quality control →	+0.145	+0.709	<.001	.003	3	11
OESOPHAGUS	Asparaginyl-tRNA aminoacylation →	+0.176	+0.978	<.001	<.001	3	11
BLOOD_Leukemia	Tetrahydrofolate metabolic process →	+0.053	+0.332	.003	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,247 associations by consensus.

Negative regulation of focal adhesion disassembly by HIKESHI expression — URINARY_TRACT

Explore this box plot interactively →