HIGD2B

Across TCGA patient cohorts, HIGD2B RNA expression is significantly associated with the go_rna of many other GO terms, with 6,815 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HIGD2B-associated GO terms across cancer lineages are Mitochondrial respiratory chain complex assembly, tRNA metabolic process, and Peroxisome fission. Each is linked with HIGD2B in more than 13 cancer types. Because this analysis shows association rather than direction, both HIGD2B-to-partner and partner-to-HIGD2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial respiratory chain complex assembly grouped by HIGD2B-low versus HIGD2B-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIGD2B→partner) and Y-score (partner→HIGD2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Mitochondrial respiratory chain complex assembly →	+0.040	+0.071	<.001	<.001	3	13
STAD	tRNA metabolic process →	+0.037	+0.080	<.001	<.001	3	12
PAAD	Peroxisome fission →	+0.034	+0.076	.001	.003	2	13
DLBC	Iron-sulfur cluster assembly →	+0.056	+0.130	.004	.007	1	14
STAD	Mitochondrial translation →	+0.041	+0.074	<.001	<.001	3	12
STAD	tRNA modification →	+0.034	+0.075	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,815 associations by consensus.

Mitochondrial respiratory chain complex assembly by HIGD2B expression — STAD

Explore this box plot interactively →