Across TCGA patient cohorts, HIGD1C RNA expression is significantly associated with the protein abundance of many other proteins, with 7,279 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible HIGD1C-associated proteins across cancer lineages are PRPF38B_S529, NELFE_S353, and EEF2_S502. Each is linked with HIGD1C in more than 2 cancer types. Because this analysis shows association rather than direction, both HIGD1C-to-partner and partner-to-HIGD1C results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HIGD1C→partner) and Y-score (partner→HIGD1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRPF38B_S529 →	+0.511	+0.715	<.001	.003	3	3
LSCC	NELFE_S353 →	+0.545	+0.484	<.001	.001	3	3
HNSC	EEF2_S502 →	-0.667	-0.573	<.001	<.001	3	3
LSCC	KMT2A_T3028 →	+0.544	+0.495	<.001	<.001	3	3
HNSC	PLS3_S339 →	-0.651	-0.787	<.001	<.001	3	3
LSCC	SLC20A2_S256 →	-1.195	-0.637	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,279 associations by consensus.

Exploration

HIGD1C survival (RNA) · tumor vs normal (RNA) · all HIGD1C data types