HIGD1A

Across TCGA patient cohorts, HIGD1A mutation is significantly associated with the RNA expression of many other genes, with 130 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIGD1A-associated genes across cancer lineages are RNA5SP414, MTCYBP20, and RPL23AP84. Each is linked with HIGD1A in more than 1 cancer types. Because this analysis shows association rather than direction, both HIGD1A-to-partner and partner-to-HIGD1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by HIGD1A-low versus HIGD1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIGD1A→partner) and Y-score (partner→HIGD1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.502	+2.577	.002	.004	3	1
BLCA	MTCYBP20 →	+0.033	+5.685	<.001	.003	3	1
BLCA	RPL23AP84 →	+0.099	+5.899	<.001	.002	3	1
BLCA	ISCA1P3 →	+0.175	+5.411	<.001	.005	3	1
UCEC	MIR3197 →	+0.665	+2.144	.007	.007	3	1
UCEC	CGB1 →	+0.066	+3.081	.008	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 130 associations by consensus.

RNA5SP414 by HIGD1A expression — UCEC

Explore this box plot interactively →