HIGD1A

Across TCGA pan-cancer cohorts, HIGD1A RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated HIGD1A data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HIGD1A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated HIGD1A expression acts as an unfavorable survival marker, although some lineages such as COAD and KIRP show a favorable association.

COAD, ESCA, and KIRP are the cancer types where HIGD1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	All	0.673	0.326	.001	74	view →
ESCA	OS	Median	II,III,IV	0.437	0.674	.002	45	view →
KIRP	OS	Tertile	II,III,IV	1.000	0.743	.005	42	view →
ACC	DFS	Quartile	All	0.219	0.798	<.001	39	view →
LAML	DFS	Quartile	All	0.443	0.843	.006	32	view →
STAD	OS	Tertile	IV	0.134	0.577	.009	24	view →
MESO	DFS	Median	II,III,IV	0.442	0.298	.010	23	view →
READ	DFS	Quartile	II,III,IV	0.798	0.283	.003	22	view →
KICH	DFS	Median	III,IV	0.370	0.894	.006	21	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	19	view →
HNSC	OS	Quartile	IV	0.260	0.490	.013	17	view →
BLCA	DFS	Quartile	IV	0.130	0.399	.010	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

HIGD1A–COAD (DFS)

Open the COAD breakdown →