HIGD1A

Across TCGA patient cohorts, HIGD1A mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIGD1A-associated genes across cancer lineages are mTOR_pS2448, p27_pT198, and PCNA. Each is linked with HIGD1A in more than 1 cancer types. Because this analysis shows association rather than direction, both HIGD1A-to-partner and partner-to-HIGD1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by HIGD1A-low versus HIGD1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIGD1A→partner) and Y-score (partner→HIGD1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.191	-2.980	.010	.036	3	1
UCEC	p27_pT198 →	+0.135	+2.321	.011	.035	3	1
UCEC	PCNA →	+0.333	+3.459	.002	.005	3	1
UCEC	STAT3_pY705 →	-0.506	-2.321	<.001	.035	3	1
UCEC	VHL →	-0.876	-2.321	.010	.035	3	1
UCEC	ATM →	-0.866	-2.321	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

mTOR_pS2448 by HIGD1A expression — UCEC

Explore this box plot interactively →