HIGD1A

Across TCGA cell cohorts, HIGD1A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,748 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HIGD1A-associated GO terms across cancer lineages are tRNA 3'-terminal CCA addition, Glial cell migration, and Meiotic sister chromatid cohesion. Each is linked with HIGD1A in more than 10 cancer types. Because this analysis shows association rather than direction, both HIGD1A-to-partner and partner-to-HIGD1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA 3'-terminal CCA addition grouped by HIGD1A-low versus HIGD1A-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIGD1A→partner) and Y-score (partner→HIGD1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	tRNA 3'-terminal CCA addition →	+0.184	+0.896	<.001	.002	3	11
LUNG_NSCLC_LUSC	Glial cell migration →	-0.160	-0.879	<.001	<.001	3	10
OESOPHAGUS	Meiotic sister chromatid cohesion →	+0.154	+0.764	<.001	.001	3	10
URINARY_TRACT	DAMP biosynthetic process →	+0.134	+0.965	<.001	.001	3	10
URINARY_TRACT	Purine deoxyribonucleoside monophosphate biosynthetic process →	+0.134	+0.965	<.001	.001	3	10
BONE	Protein localization to early endosome →	+0.261	+0.976	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,748 associations by consensus.

tRNA 3'-terminal CCA addition by HIGD1A expression — LIVER

Explore this box plot interactively →