HIF3A

Across TCGA pan-cancer cohorts, HIF3A mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of HIF3A’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where HIF3A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types HIF3A is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

CCRCC are the cancer types where HIF3A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HIF3A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	−3.168	<.001	11	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

HIF3A–CCRCC

Open the CCRCC breakdown →