HIF3A

Across TCGA pan-cancer cohorts, HIF3A RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HIF3A data layer compared with 13 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HIF3A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HIF3A expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

UCEC, UCS, and HNSC are the cancer types where HIF3A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.603	0.735	<.001	86	view →
UCS	DFS	Quartile	III,IV	0.837	0.215	<.001	58	view →
HNSC	DFS	Quartile	IV	0.480	0.188	<.001	57	view →
OV	OS	Median	All	0.793	0.886	.004	52	view →
ACC	DFS	Tertile	All	0.901	0.409	<.001	50	view →
THCA	OS	Tertile	All	0.877	0.988	.002	36	view →
SCLC	DFS	Median	II,III,IV	0.189	0.513	.003	25	view →
BLCA	OS	Median	IV	0.237	0.556	.013	21	view →
KIRP	OS	Quartile	II,III,IV	0.665	0.910	.027	14	view →
SARC	DFS	Tertile	All	0.718	0.526	.006	12	view →
UVM	DFS	Tertile	All	0.535	0.927	.010	11	view →
SKCM	OS	Quartile	III,IV	0.812	0.503	.013	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HIF3A–UCEC (OS)

Open the UCEC breakdown →