HIF3A

Across TCGA patient cohorts, HIF3A protein abundance is significantly associated with the RNA expression of many other genes, with 304 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HIF3A-associated genes across cancer lineages are CNTNAP1, TNFSF10, and GHRL. Each is linked with HIF3A in more than 1 cancer types. Because this analysis shows association rather than direction, both HIF3A-to-partner and partner-to-HIF3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HIF3A versus CNTNAP1 in CCRCC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIF3A→partner) and Y-score (partner→HIF3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CNTNAP1 →	+0.612	+0.919	.006	.003	3	1
CCRCC	TNFSF10 →	+1.138	+1.063	.003	.007	3	1
CCRCC	GHRL →	+0.437	+0.928	.002	.002	3	1
CCRCC	CD1E →	+0.446	+1.248	.001	.003	3	1
CCRCC	NRROS →	+0.482	+1.146	.009	.007	3	1
CCRCC	OR52N2 →	-0.442	-0.932	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 304 associations by consensus.

HIF3A vs CNTNAP1 — CCRCC

Explore this scatter interactively →