HIF3A

Across TCGA patient cohorts, HIF3A mutation is significantly associated with the RNA expression of many other genes, with 3,101 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIF3A-associated genes across cancer lineages are PNPP1, APOOP2, and NDUFA6. Each is linked with HIF3A in more than 3 cancer types. Because this analysis shows association rather than direction, both HIF3A-to-partner and partner-to-HIF3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNPP1 grouped by HIF3A-low versus HIF3A-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIF3A→partner) and Y-score (partner→HIF3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PNPP1 →	+0.027	+4.587	<.001	<.001	3	4
READ	APOOP2 →	+0.699	+5.039	<.001	.008	3	3
UCEC	NDUFA6 →	+0.505	+3.269	<.001	<.001	3	3
COAD	CIB1 →	+0.636	+3.200	<.001	.009	3	3
COAD	RPS19BP1 →	+0.541	+3.362	<.001	.005	3	3
COAD	COX6CP5 →	+0.100	+4.239	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,101 associations by consensus.

PNPP1 by HIF3A expression — BRCA

Explore this box plot interactively →