HIF3A

Across TCGA patient cohorts, HIF3A mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIF3A-associated genes across cancer lineages are c-Met, Notch1, and p62 Lck ligand. Each is linked with HIF3A in more than 1 cancer types. Because this analysis shows association rather than direction, both HIF3A-to-partner and partner-to-HIF3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met grouped by HIF3A-low versus HIF3A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIF3A→partner) and Y-score (partner→HIF3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	c-Met →	-0.103	-1.687	.036	.040	3	2
UCEC	Notch1 →	+0.133	+1.678	.013	.023	3	2
UCEC	p62 Lck ligand →	+0.375	+3.700	.002	.001	3	2
UCEC	Chk2_pT68 →	-0.162	-2.575	.023	.010	3	2
SKCM	PI3K-p110-a →	+0.124	+1.321	.015	.028	3	1
SKCM	CD49b →	+0.173	+1.485	.027	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

c-Met by HIF3A expression — SKCM

Explore this box plot interactively →