HIF3A

Across TCGA cell cohorts, HIF3A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,396 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HIF3A-associated GO terms across cancer lineages are Protein localization to vacuole, Protein localization to cytoplasmic stress granule, and Negative regulation of mRNA metabolic process. Each is linked with HIF3A in more than 6 cancer types. Because this analysis shows association rather than direction, both HIF3A-to-partner and partner-to-HIF3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to vacuole grouped by HIF3A-low versus HIF3A-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIF3A→partner) and Y-score (partner→HIF3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Protein localization to vacuole →	+0.065	+1.586	<.001	.002	3	7
SOFT_TISSUE	Protein localization to cytoplasmic stress granule →	+0.127	+0.694	<.001	.004	3	7
OVARY	Negative regulation of mRNA metabolic process →	+0.085	+1.926	<.001	<.001	3	6
OVARY	Electron transport chain →	+0.115	+1.400	<.001	<.001	3	6
OVARY	Negative regulation of mRNA splicing, via spliceosome →	+0.051	+0.885	.002	.007	3	6
BONE	Ribonucleotide biosynthetic process →	+0.090	+2.064	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,396 associations by consensus.

Protein localization to vacuole by HIF3A expression — LUNG_SCLC

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