HIF3A

Across TCGA cell cohorts, HIF3A mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible HIF3A-associated genes across cancer lineages are SPATA48, PFN3, and SIGLEC6. Each is linked with HIF3A in more than 1 cancer types. Because this analysis shows association rather than direction, both HIF3A-to-partner and partner-to-HIF3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA48 grouped by HIF3A-low versus HIF3A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIF3A→partner) and Y-score (partner→HIF3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPATA48 →	+0.011	+3.977	<.001	.001	3	2
OVARY	PFN3 →	+0.053	+3.865	<.001	.001	3	2
LUNG_SCLC	SIGLEC6 →	+0.102	+4.256	<.001	.002	3	1
LUNG_SCLC	LCE3D →	+0.063	+3.817	<.001	.004	3	1
LUNG_SCLC	IQCF1 →	+0.137	+3.898	<.001	.005	3	1
LUNG_SCLC	DEFB125 →	+0.052	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

SPATA48 by HIF3A expression — SKIN

Explore this box plot interactively →