HIF1AP1

Across TCGA pan-cancer cohorts, HIF1AP1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated HIF1AP1 data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher HIF1AP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HIF1AP1 expression acts as an unfavorable survival marker, although some lineages such as UCS and UCEC show a favorable association.

READ, KICH, and ACC are the cancer types where HIF1AP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Tertile	II,III,IV	0.801	0.950	.002	45	view →
KICH	OS	Tertile	III,IV	0.162	0.808	.001	32	view →
ACC	DFS	Tertile	IV	0.066	0.334	.028	32	view →
KIRC	OS	Quartile	All	0.732	0.821	.002	30	view →
GBM	OS	Median	All	0.276	0.485	<.001	30	view →
UCS	DFS	Median	IV	0.952	0.473	.018	30	view →
MESO	OS	Tertile	II,III,IV	0.162	0.583	.017	27	view →
UCEC	OS	Tertile	III,IV	0.896	0.791	.027	20	view →
STAD	DFS	Quartile	II,III,IV	0.497	0.655	.027	15	view →
PRAD	OS	Quartile	All	0.760	0.989	<.001	14	view →
COAD	DFS	Tertile	All	0.257	0.574	.014	10	view →
HNSC	OS	Tertile	II,III,IV	0.244	0.451	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

HIF1AP1–READ (OS)

Open the READ breakdown →