HIF1AP1

Across TCGA pan-cancer cohorts, HIF1AP1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HIF1AP1’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where HIF1AP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HIF1AP1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

STAD, THCA, and COAD are the cancer types where HIF1AP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HIF1AP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Female	All	+0.385	.001	4	view →
THCA	All	II,III,IV	−0.195	.026	2	view →
COAD	All	All	+0.169	.026	2	view →
BRCA	All	All	+0.163	.030	2	view →
KICH	Female	III,IV	+0.506	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

HIF1AP1–STAD

Open the STAD breakdown →