HIF1AN

Across TCGA patient cohorts, HIF1AN mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIF1AN-associated genes across cancer lineages are eEF2, EGFR_pY1068, and A-Raf_pS299. Each is linked with HIF1AN in more than 1 cancer types. Because this analysis shows association rather than direction, both HIF1AN-to-partner and partner-to-HIF1AN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by HIF1AN-low versus HIF1AN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIF1AN→partner) and Y-score (partner→HIF1AN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.345	+1.906	.016	.016	3	1
UCEC	EGFR_pY1068 →	-0.274	-3.700	.006	.001	3	1
UCEC	A-Raf_pS299 →	-0.179	-3.321	<.001	.010	3	1
UCEC	ERK2 →	+0.259	+2.415	<.001	.003	3	1
UCEC	GATA6 →	-0.125	-1.899	.045	.016	3	1
UCEC	INPP4B →	-0.310	-2.321	.017	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eEF2 by HIF1AN expression — UCEC

Explore this box plot interactively →