HIF1AN

Across TCGA pan-cancer cohorts, HIF1AN RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HIF1AN data layer compared with 2 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HIF1AN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HIF1AN expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

ACC, LIHC, and UCS are the cancer types where HIF1AN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.239	0.658	<.001	80	view →
LIHC	DFS	Tertile	All	0.433	0.606	<.001	56	view →
UCS	OS	Quartile	III,IV	0.758	0.280	.002	54	view →
OV	OS	Median	All	0.792	0.885	<.001	54	view →
KIRC	OS	Median	All	0.734	0.546	<.001	49	view →
LGG	DFS	Median	All	0.873	0.787	<.001	34	view →
MESO	DFS	Tertile	II,III,IV	0.263	0.669	.012	30	view →
HNSC	DFS	Quartile	IV	0.524	0.286	<.001	29	view →
SCLC	DFS	Median	II,III,IV	0.821	0.203	.001	26	view →
KICH	OS	Quartile	All	0.790	1.000	.008	25	view →
BLCA	DFS	Tertile	II,III,IV	0.427	0.559	.021	17	view →
THCA	OS	Median	II,III,IV	0.860	0.979	.017	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HIF1AN–ACC (DFS)

Open the ACC breakdown →