HIF1AN

Across TCGA cell cohorts, HIF1AN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,347 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HIF1AN-associated GO terms across cancer lineages are Viral translational termination-reinitiation, Regulation of smoothened signaling pathway, and Retrograde transport, endosome to Golgi. Each is linked with HIF1AN in more than 17 cancer types. Because this analysis shows association rather than direction, both HIF1AN-to-partner and partner-to-HIF1AN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral translational termination-reinitiation grouped by HIF1AN-low versus HIF1AN-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIF1AN→partner) and Y-score (partner→HIF1AN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Viral translational termination-reinitiation →	+0.092	+0.807	<.001	<.001	3	18
OESOPHAGUS	Regulation of smoothened signaling pathway →	+0.051	+1.313	.007	<.001	3	17
OESOPHAGUS	Retrograde transport, endosome to Golgi →	+0.100	+1.228	<.001	<.001	3	17
LUNG_SCLC	Regulation of sister chromatid cohesion →	+0.134	+0.951	<.001	<.001	3	17
KIDNEY	Regulation of mitotic cytokinetic process →	+0.145	+0.823	.001	<.001	3	17
KIDNEY	Positive regulation of mitotic cytokinetic process →	+0.145	+0.823	.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,347 associations by consensus.

Viral translational termination-reinitiation by HIF1AN expression — BLOOD_Lymphoma

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