HIF1A-AS3

Across TCGA pan-cancer cohorts, HIF1A-AS3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HIF1A-AS3 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher HIF1A-AS3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HIF1A-AS3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and TGCT show a favorable association.

KICH, CESC, and KIRP are the cancer types where HIF1A-AS3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	III,IV	0.222	0.913	.002	82	view →
CESC	OS	Tertile	All	0.832	0.942	<.001	78	view →
KIRP	DFS	Quartile	III,IV	0.250	0.683	.001	69	view →
UVM	DFS	Tertile	II,III,IV	0.307	0.769	.003	68	view →
STAD	DFS	Median	All	0.319	0.599	.009	57	view →
ACC	DFS	Median	All	0.517	0.793	<.001	38	view →
LUAD	DFS	Quartile	All	0.754	0.875	.001	29	view →
KIRC	OS	Median	All	0.910	0.836	<.001	27	view →
THCA	OS	Tertile	All	0.850	0.976	.003	27	view →
COAD	DFS	Median	All	0.741	0.823	.007	26	view →
BLCA	DFS	Median	All	0.504	0.684	.011	16	view →
TGCT	DFS	Median	All	0.911	0.673	<.001	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HIF1A-AS3–KICH (DFS)

Open the KICH breakdown →