HIF1A-AS3

Across TCGA pan-cancer cohorts, HIF1A-AS3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HIF1A-AS3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HIF1A-AS3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HIF1A-AS3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where HIF1A-AS3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HIF1A-AS3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.639	<.001	12	view →
HNSC	Male	II,III,IV	+0.812	<.001	12	view →
KIRP	All	II,III,IV	+0.979	.004	8	view →
LUAD	All	All	+0.794	<.001	7	view →
THCA	All	II,III,IV	−0.306	.013	5	view →
BRCA	Female	II,III,IV	+0.355	.004	4	view →
COAD	All	All	+0.243	.013	4	view →
CHOL	Female	All	+0.740	<.001	3	view →
PAAD	All	All	+1.697	.041	2	view →
LUSC	Male	All	+0.632	<.001	2	view →
READ	Male	All	+0.576	.037	2	view →
KICH	Female	All	−0.511	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HIF1A-AS3–KIRC

Open the KIRC breakdown →