HIF1A-AS1

Across TCGA pan-cancer cohorts, HIF1A-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated HIF1A-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HIF1A-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HIF1A-AS1 expression acts as an unfavorable survival marker, although some lineages such as DLBC and LUSC show a favorable association.

ACC, BLCA, and LUAD are the cancer types where HIF1A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.771	0.960	.002	64	view →
BLCA	OS	Median	All	0.659	0.757	.004	32	view →
LUAD	OS	Tertile	All	0.305	0.513	<.001	31	view →
KIRC	DFS	Median	IV	0.301	0.586	.015	25	view →
DLBC	DFS	Tertile	All	0.940	0.601	.006	19	view →
LUSC	DFS	Median	All	0.803	0.684	<.001	18	view →
THCA	DFS	Median	IV	0.454	0.865	.002	14	view →
PRAD	DFS	Median	All	0.858	0.705	.021	14	view →
SKCM	OS	Quartile	All	0.496	0.294	.003	13	view →
KIRP	DFS	Median	II,III,IV	0.660	0.868	.030	13	view →
UCS	DFS	Tertile	IV	0.981	0.580	.024	12	view →
READ	DFS	Tertile	IV	0.179	0.936	.010	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

HIF1A-AS1–ACC (OS)

Open the ACC breakdown →