HIF1A-AS1

Across TCGA pan-cancer cohorts, HIF1A-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HIF1A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HIF1A-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HIF1A-AS1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, KICH, and KIRC are the cancer types where HIF1A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HIF1A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.561	<.001	12	view →
KICH	Male	IV	−1.216	<.001	11	view →
KIRC	Male	II,III,IV	−0.409	<.001	10	view →
LUAD	All	II,III,IV	+0.361	<.001	8	view →
UCEC	All	III,IV	+0.592	.007	6	view →
LUSC	All	All	+0.411	<.001	5	view →
THCA	All	All	−0.180	.006	3	view →
LIHC	Female	All	+0.120	.003	3	view →
CHOL	All	All	+0.311	.001	2	view →
BLCA	All	III,IV	+0.233	.047	1	view →
STAD	All	III,IV	+0.155	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HIF1A-AS1–HNSC

Open the HNSC breakdown →