HID1-AS1

Across TCGA pan-cancer cohorts, HID1-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HID1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HID1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types HID1-AS1 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, KIRP, and LUAD are the cancer types where HID1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HID1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.000	<.001	11	view →
KIRP	All	II,III,IV	−0.756	<.001	11	view →
LUAD	Female	III,IV	−1.950	<.001	9	view →
KICH	Male	II,III,IV	−0.758	<.001	9	view →
LUSC	Female	II,III,IV	−2.177	<.001	8	view →
UCEC	All	III,IV	−1.407	<.001	8	view →
BLCA	All	All	−0.397	.004	8	view →
COAD	All	II,III,IV	−0.277	<.001	8	view →
BRCA	All	II,III,IV	−1.167	<.001	6	view →
LIHC	All	All	−0.231	<.001	6	view →
KIRC	All	All	+0.327	.001	3	view →
HNSC	Female	IV	+0.266	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HID1-AS1–THCA

Open the THCA breakdown →