HHLA1

Across TCGA patient cohorts, HHLA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,784 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HHLA1-associated GO terms across cancer lineages are Regulation of microtubule-based process, Cellular respiration, and Positive regulation of translation. Each is linked with HHLA1 in more than 12 cancer types. Because this analysis shows association rather than direction, both HHLA1-to-partner and partner-to-HHLA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of microtubule-based process grouped by HHLA1-low versus HHLA1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HHLA1→partner) and Y-score (partner→HHLA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of microtubule-based process →	+0.053	+0.051	<.001	.009	1	13
STAD	Cellular respiration →	+0.097	+0.058	<.001	<.001	2	10
STAD	Positive regulation of translation →	+0.086	+0.064	<.001	<.001	3	9
STAD	Pyrimidine nucleoside triphosphate biosynthetic process →	+0.066	+0.065	<.001	<.001	3	9
STAD	tRNA metabolic process →	+0.084	+0.059	<.001	.001	2	9
STAD	rRNA metabolic process →	+0.099	+0.058	<.001	.001	1	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,784 associations by consensus.

Regulation of microtubule-based process by HHLA1 expression — ESCA

Explore this box plot interactively →