HHLA1

Across TCGA patient cohorts, HHLA1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,393 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HHLA1-associated genes across cancer lineages are TP53AIP1, ADGRB2, and TLCD3B. Each is linked with HHLA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HHLA1-to-partner and partner-to-HHLA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HHLA1 versus TP53AIP1 in UCEC, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHLA1→partner) and Y-score (partner→HHLA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TP53AIP1 →	+1.136	+1.531	.004	.002	3	2
UCEC	ADGRB2 →	+0.748	+1.919	<.001	<.001	3	2
GBM	TLCD3B →	+0.377	+0.268	.007	.003	3	2
GBM	KCNN1 →	+0.762	+0.309	.005	.008	3	2
GBM	SLC14A1 →	+1.537	+0.384	<.001	<.001	3	2
CCRCC	RHOB →	+0.745	+0.265	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,393 associations by consensus.

HHLA1 vs TP53AIP1 — UCEC

Explore this scatter interactively →