HHLA1

Across TCGA patient cohorts, HHLA1 mutation is significantly associated with the RNA expression of many other genes, with 3,285 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HHLA1-associated genes across cancer lineages are MTND4LP19, RN7SL83P, and PCNPP3. Each is linked with HHLA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HHLA1-to-partner and partner-to-HHLA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND4LP19 grouped by HHLA1-low versus HHLA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHLA1→partner) and Y-score (partner→HHLA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTND4LP19 →	+0.150	+4.225	.003	.007	3	2
COAD	RN7SL83P →	+0.310	+4.070	<.001	.009	3	2
BRCA	PCNPP3 →	+0.254	+3.579	<.001	.009	3	2
BRCA	GAPDHP75 →	+0.037	+3.513	.001	.008	3	2
UCEC	EZH2P1 →	+0.203	+1.569	.007	.005	3	2
BRCA	FAM74A6 →	+0.013	+4.324	.009	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,285 associations by consensus.

MTND4LP19 by HHLA1 expression — COAD

Explore this box plot interactively →