HHLA1

Across TCGA patient cohorts, HHLA1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HHLA1-associated genes across cancer lineages are 14-3-3_beta, ERK2, and G6PD. Each is linked with HHLA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HHLA1-to-partner and partner-to-HHLA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by HHLA1-low versus HHLA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHLA1→partner) and Y-score (partner→HHLA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.082	-2.680	.021	.006	3	1
UCEC	ERK2 →	+0.170	+1.362	.012	.037	3	1
UCEC	G6PD →	-0.225	-1.680	.049	.042	3	1
UCEC	JNK2 →	+0.221	+3.611	.001	.001	3	1
UCEC	Ku80 →	+0.262	+2.013	.001	.001	3	1
UCEC	MEK1 →	+0.328	+2.700	.011	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

14-3-3_beta by HHLA1 expression — UCEC

Explore this box plot interactively →