HHLA1

Across TCGA cell cohorts, HHLA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 560 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible HHLA1-associated GO terms across cancer lineages are Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, Regulation of nuclear-transcribed mRNA poly(A) tail shortening, and Establishment of RNA localization. Each is linked with HHLA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HHLA1-to-partner and partner-to-HHLA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening grouped by HHLA1-low versus HHLA1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HHLA1→partner) and Y-score (partner→HHLA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening →	+0.122	+0.004	.001	.009	3	4
KIDNEY	Regulation of nuclear-transcribed mRNA poly(A) tail shortening →	+0.079	+0.004	.003	.002	3	4
OESOPHAGUS	Establishment of RNA localization →	+0.085	+0.100	.007	.004	3	4
BLOOD_Leukemia	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.054	+0.002	.003	.007	3	4
OESOPHAGUS	Positive regulation of protein localization to centrosome →	+0.119	+0.097	<.001	.001	2	4
KIDNEY	Regulation of glucose metabolic process →	+0.043	+0.005	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 560 associations by consensus.

Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening by HHLA1 expression — KIDNEY

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