HHLA1

Across TCGA cell cohorts, HHLA1 mutation is significantly associated with the RNA expression of many other genes, with 114 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HHLA1-associated genes across cancer lineages are OR4D6, SUPT20HL1, and IFNA17. Each is linked with HHLA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HHLA1-to-partner and partner-to-HHLA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4D6 grouped by HHLA1-low versus HHLA1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHLA1→partner) and Y-score (partner→HHLA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR4D6 →	+0.012	+4.807	<.001	.003	3	1
OVARY	SUPT20HL1 →	+0.092	+4.807	<.001	.003	3	1
OVARY	IFNA17 →	+0.015	+4.807	<.001	.003	3	1
LUNG_NSCLC_LUAD	ARMH2 →	+0.037	+4.189	<.001	.002	3	1
LARGE_INTESTINE	POLR3G →	+1.048	+3.212	.007	.006	3	1
LARGE_INTESTINE	FBXO6 →	+1.457	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

OR4D6 by HHLA1 expression — OVARY

Explore this box plot interactively →