HHLA1

Across TCGA cell cohorts, HHLA1 mutation is significantly associated with the mutation status of many other genes, with 4,202 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HHLA1-associated genes across cancer lineages are CCDC190, INTS13, and TAB2. Each is linked with HHLA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HHLA1-to-partner and partner-to-HHLA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC190 grouped by HHLA1-low versus HHLA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHLA1→partner) and Y-score (partner→HHLA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC190 →	+4.056	+3.263	<.001	<.001	1	4
LUNG_NSCLC_LUAD	INTS13 →	+5.000	+4.187	.008	.008	1	3
OVARY	TAB2 →	+3.977	+4.930	.001	.001	1	3
OVARY	CELSR1 →	+3.240	+4.467	.004	.004	1	3
SKIN	CTTNBP2 →	+3.316	+3.906	.004	.004	1	3
SKIN	CTCF →	+4.053	+4.357	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,202 associations by consensus.

CCDC190 by HHLA1 expression — LARGE_INTESTINE

Explore this box plot interactively →