HHIP

Across TCGA patient cohorts, HHIP mutation is significantly associated with the RNA expression of many other genes, with 4,159 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HHIP-associated genes across cancer lineages are RNA5SP457, SFXN1, and TAF9. Each is linked with HHIP in more than 2 cancer types. Because this analysis shows association rather than direction, both HHIP-to-partner and partner-to-HHIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP457 grouped by HHIP-low versus HHIP-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHIP→partner) and Y-score (partner→HHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP457 →	+0.323	+3.758	<.001	.008	3	3
COAD	SFXN1 →	+0.542	+3.210	.002	.009	3	3
UCEC	TAF9 →	+0.525	+2.280	<.001	<.001	3	3
UCEC	H2AC14 →	+0.732	+2.673	<.001	<.001	3	3
UCEC	TNFSF13B →	+0.628	+1.632	<.001	<.001	3	3
UCEC	RAD51C →	+0.437	+2.055	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,159 associations by consensus.

RNA5SP457 by HHIP expression — BLCA

Explore this box plot interactively →