HHIP

Across TCGA pan-cancer cohorts, HHIP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HHIP’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HHIP RNA is repressed in tumor relative to normal tissue. In most cancer types HHIP is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and LUAD are the cancer types where HHIP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HHIP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−1.352	<.001	11	view →
THCA	Female	II,III,IV	−0.653	<.001	11	view →
LUAD	Male	III,IV	−3.711	<.001	9	view →
LUSC	Female	II,III,IV	−3.945	<.001	8	view →
KICH	All	All	−0.557	<.001	8	view →
LIHC	Male	III,IV	−1.940	<.001	7	view →
KIRP	Female	All	−0.639	<.001	7	view →
UCEC	All	III,IV	+1.208	.003	6	view →
KIRC	All	All	−0.515	<.001	6	view →
BRCA	All	All	−0.140	<.001	6	view →
READ	All	All	−1.275	<.001	5	view →
CHOL	All	All	−1.005	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HHIP–COAD

Open the COAD breakdown →