HHIP

Across TCGA cell cohorts, HHIP RNA expression is significantly associated with the go_rna of many other GO terms, with 2,640 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HHIP-associated GO terms across cancer lineages are Positive regulation of stress fiber assembly, Anaphase-promoting complex-dependent catabolic process, and Spindle assembly. Each is linked with HHIP in more than 8 cancer types. Because this analysis shows association rather than direction, both HHIP-to-partner and partner-to-HHIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of stress fiber assembly grouped by HHIP-low versus HHIP-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HHIP→partner) and Y-score (partner→HHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of stress fiber assembly →	+0.103	+1.028	<.001	.006	3	9
LUNG_NSCLC_LUAD	Anaphase-promoting complex-dependent catabolic process →	+0.063	+0.811	.001	<.001	3	9
BLOOD_Leukemia	Spindle assembly →	+0.050	+1.191	<.001	<.001	3	8
BLOOD_Leukemia	Microtubule cytoskeleton organization involved in mitosis →	+0.068	+1.742	<.001	<.001	3	8
BLOOD_Leukemia	Regulation of metaphase/anaphase transition of cell cycle →	+0.056	+1.368	<.001	<.001	3	7
BREAST	Cell division →	+0.090	+0.569	<.001	.008	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,640 associations by consensus.

Positive regulation of stress fiber assembly by HHIP expression — BREAST

Explore this box plot interactively →