HHIP

Across TCGA cell cohorts, HHIP mutation is significantly associated with the RNA expression of many other genes, with 221 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HHIP-associated genes across cancer lineages are MCHR2, LACTBL1, and PSKH2. Each is linked with HHIP in more than 1 cancer types. Because this analysis shows association rather than direction, both HHIP-to-partner and partner-to-HHIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCHR2 grouped by HHIP-low versus HHIP-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHIP→partner) and Y-score (partner→HHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MCHR2 →	+0.291	+4.927	<.001	.001	3	2
BLOOD_Lymphoma	LACTBL1 →	+0.009	+4.643	<.001	.005	3	2
LUNG_NSCLC_LUAD	PSKH2 →	+0.021	+4.887	<.001	.009	3	2
OVARY	RBMY1A1 →	+0.086	+4.222	<.001	.006	3	1
LARGE_INTESTINE	PLA2G3 →	+1.210	+2.862	<.001	.001	3	1
LARGE_INTESTINE	GCAT →	+0.948	+3.169	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 221 associations by consensus.

MCHR2 by HHIP expression — BLOOD_Lymphoma

Explore this box plot interactively →