HHIP-AS1

Across TCGA pan-cancer cohorts, HHIP-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HHIP-AS1 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher HHIP-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HHIP-AS1 expression acts as an unfavorable survival marker, although some lineages such as LAML and BRCA show a favorable association.

LGG, UVM, and STAD are the cancer types where HHIP-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.351	0.519	<.001	54	view →
UVM	DFS	Median	All	0.277	0.619	.010	36	view →
STAD	OS	Quartile	All	0.403	0.650	.007	31	view →
LAML	DFS	Median	All	0.510	0.248	.002	28	view →
BRCA	OS	Tertile	III,IV	0.886	0.739	.002	24	view →
LUSC	DFS	Quartile	II,III,IV	0.634	0.826	.004	22	view →
UCS	DFS	Tertile	III,IV	0.524	0.188	.004	18	view →
DLBC	OS	Median	All	1.000	0.226	.009	16	view →
THYM	OS	Tertile	II,III,IV	1.000	0.532	.003	13	view →
GBM	DFS	Tertile	All	0.491	0.218	.003	12	view →
MESO	OS	Quartile	III,IV	0.842	0.263	.017	12	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HHIP-AS1–LGG (OS)

Open the LGG breakdown →