HHIP-AS1

Across TCGA pan-cancer cohorts, HHIP-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HHIP-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HHIP-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types HHIP-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and COAD are the cancer types where HHIP-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HHIP-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−1.085	<.001	11	view →
KICH	Female	All	−1.369	<.001	10	view →
COAD	Female	II,III,IV	−0.747	<.001	10	view →
LUAD	Female	III,IV	−2.716	<.001	9	view →
LUSC	Male	II,III,IV	−2.550	<.001	9	view →
BRCA	All	II,III,IV	−0.503	<.001	6	view →
BLCA	All	All	−1.089	.009	5	view →
READ	All	All	−0.870	<.001	5	view →
LIHC	Male	All	−0.916	<.001	4	view →
PRAD	All	All	−0.693	<.001	2	view →
KIRC	All	All	−0.324	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HHIP-AS1–THCA

Open the THCA breakdown →